Scientific Publications

Transferrin Non-Viral Gene Therapy for Treatment of Retinal Degeneration

Karine Bigot, Pauline Gondouin, Romain Bénard, Pierrick Montagne, Jenny Youale, Marie Piazza, Emilie Picard, Thierry Bordet,* and Francine Behar-Cohen
Pharmaceutics 2020, 12, 836; doi:10.3390/pharmaceutics12090836

Ocular gene therapies in clinical practice: viral vectors and nonviral alternatives

Thierry Bordet and Francine Behar-Cohen

Drug Discovery Today, Volume 24, Issue 8, August 2019, Pages 1685-1693

Non-viral ocular gene therapy, pEYS606, for the treatment of non-infectious
uveitis: Preclinical evaluation of the medicinal product

Elodie Touchard, Romain Benard, Karine Bigot, Jean-Denis Laffitte , Ronald Buggage, Thierry Bordet, Francine Behar-Cohen.

Journal of Controlled Release, vol. 285 (2018): 244-251

Long-term efficacy of ciliary muscle gene transfer of three sFlt-1 variants in a rat model of laser-induced choroidal neovascularization.

El Sanharawi M, Touchard E, Benard R, Bigey P, Escriou V, Mehanna C, Naud MC, Berdugo M, Jeanny JC, Behar-Cohen F.
Gene Therapy vol. 20,11 (2013): 1093-103

Non-viral gene therapy for GDNF production in RCS rat: the crucial role of the plasmid dose.

Touchard E, Heiduschka P, Berdugo M, Kowalczuk L, Bigey P, Chahory S, Gandolphe C, Jeanny JC, Behar-Cohen F.
Gene Therapy vol. 19,9 (2012): 886-98

The ciliary smooth muscle electrotransfer: basic principles and potential for sustained intraocular production of therapeutic proteins.

Touchard E, Kowalczuk L, Bloquel C, Naud MC, Bigey P, Behar-Cohen F.
J Gene Med, 2010. 12(11):904-19

Protein delivery for retinal diseases: from basic considerations to clinical applications.

El Sanharawi M, Kowalczuk L, Touchard E, Omri S, de Kozak Y, Behar-Cohen F.
Prog Retin Eye Res, 2010. 29(6):443-65. Review

Effects of ciliary muscle plasmid electrotransfer of TNF-alpha soluble receptor variants in experimental uveitis.

Touchard E, Bloquel C, Bigey P, Kowalczuk L, Jonet L, Thillaye-Goldenberg B, Naud MC, Scherman D, de Kozak Y, Benezra D, Behar-Cohen F.
Gene Ther, 2009. 16(7):862-73

Local ocular immunomodulation resulting from electrotransfer of plasmid encoding soluble TNF receptors in the ciliary muscle.

Kowalczuk L, Touchard E, Camelo S, Naud MC, Castaneda B, Brunel N, Besson-Lescure B, Thillaye-Goldenberg B, Bigey P, BenEzra D, de Kozak Y, Behar-Cohen F.
Invest Ophthalmol Vis Sci, 2009. 50(4):1761-8

Electrically assisted ocular gene therapy.

Bejjani RA, Andrieu C, Bloquel C, Berdugo M, BenEzra D, Behar-Cohen F.
SurvOphthalmol, 2007. 52(2):196-208. Review

Non-viral ocular gene therapy: potential ocular therapeutic avenues.

Bloquel C, Bourges JL, Touchard E, Berdugo M, BenEzra D, Behar-Cohen F.
Adv Drug DelivRev, 2006. 58(11):1224-42. Review

Plasmid electrotransfer of eye ciliary muscle: principles and therapeutic efficacy using hTNF-alpha soluble receptor in uveitis.

Bloquel C, Bejjani R, Bigey P, Bedioui F, Doat M, BenEzra D, Scherman D, Behar-Cohen F.
FASEB J, 2006. 20(2):389-91